GLAST, the space-based gamma-ray observatory from NASA, is now operational and has started collecting data. GLAST will be able to observe much higher energy gamma rays compared to the Swift satellite, which should open a new view to the skies.
While it’s a sure thing that GLAST will be observing known things such as gamma-ray bursts, active galactic nuclei, and supernova remnants, it might even make breakthroughs in physics by observing annihilation of dark matter particles or violations of Lorentz invariance.